Genomic prediction of reproduction traits for Merino sheep

Autor:	Ben J. Hayes, S. Bolormaa, Andrew Swan, Daniel Brown, Hans D. Daetwyler, J. H. J. van der Werf
Rok vydání:	2017
Předmět:	Male 0301 basic medicine Litter (animal) Genotype Litter Size media_common.quotation_subject Weaning Breeding Biology Best linear unbiased prediction Polymorphism Single Nucleotide 03 medical and health sciences symbols.namesake Statistics Genetics Animals Sheep Domestic Selection (genetic algorithm) media_common Genome Models Genetic Reproduction Sire 0402 animal and dairy science Genomics 04 agricultural and veterinary sciences General Medicine 040201 dairy & animal science Pearson product-moment correlation coefficient Phenotype 030104 developmental biology Genetic gain symbols Trait Female Animal Science and Zoology
Zdroj:	Animal Genetics. 48:338-348
ISSN:	0268-9146
DOI:	10.1111/age.12541
Popis:	Economically important reproduction traits in sheep, such as number of lambs weaned and litter size, are expressed only in females and later in life after most selection decisions are made, which makes them ideal candidates for genomic selection. Accurate genomic predictions would lead to greater genetic gain for these traits by enabling accurate selection of young rams with high genetic merit. The aim of this study was to design and evaluate the accuracy of a genomic prediction method for female reproduction in sheep using daughter trait deviations (DTD) for sires and ewe phenotypes (when individual ewes were genotyped) for three reproduction traits: number of lambs born (NLB), litter size (LSIZE) and number of lambs weaned. Genomic best linear unbiased prediction (GBLUP), BayesR and pedigree BLUP analyses of the three reproduction traits measured on 5340 sheep (4503 ewes and 837 sires) with real and imputed genotypes for 510 174 SNPs were performed. The prediction of breeding values using both sire and ewe trait records was validated in Merino sheep. Prediction accuracy was evaluated by across sire family and random cross-validations. Accuracies of genomic estimated breeding values (GEBVs) were assessed as the mean Pearson correlation adjusted by the accuracy of the input phenotypes. The addition of sire DTD into the prediction analysis resulted in higher accuracies compared with using only ewe records in genomic predictions or pedigree BLUP. Using GBLUP, the average accuracy based on the combined records (ewes and sire DTD) was 0.43 across traits, but the accuracies varied by trait and type of cross-validations. The accuracies of GEBVs from random cross-validations (range 0.17-0.61) were higher than were those from sire family cross-validations (range 0.00-0.51). The GEBV accuracies of 0.41-0.54 for NLB and LSIZE based on the combined records were amongst the highest in the study. Although BayesR was not significantly different from GBLUP in prediction accuracy, it identified several candidate genes which are known to be associated with NLB and LSIZE. The approach provides a way to make use of all data available in genomic prediction for traits that have limited recording.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ebc8a21c6728baff0bc3708772f54d https://doi.org/10.1111/age.12541 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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