Selective breeding for oral opioid acceptance or rejection in rats
| Autor: | Marjorie S. Moolten, Claudette M. Saulnier-Dyer, Kristin R. Carlson |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Narcotics Clinical Biochemistry Administration Oral Self Administration Pharmacology Toxicology Selective breeding Biochemistry Behavioral Neuroscience Control line Medicine Animals Biological Psychiatry Sex Characteristics business.industry Rats Inbred Strains Opioid-Related Disorders Preference Rats Opioid Genetic selection Benzimidazoles Female Opiate business Self-administration Etonitazene medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 53(4) |
| ISSN: | 0091-3057 |
| Popis: | Lines of rats were selectively bred to diverge bidirectionally from a randomly bred control line in the propensity to self-administer an opioid orally. These lines seek or avoid the high-potency opioid etonitazene in a situation in which it is presented continuously as a choice with water. Over seven generations, preferences were measured and selection pressure imposed to develop the accepting and rejecting lines. These animals represent the only contemporary selective breeding program for opioid preference or self-administration, and hold the promise of being a useful resource in the drug-abuse field. |
| Databáze: | OpenAIRE |
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