Investigations of droloxifene and other hormone manipulations onN-nitrosomethylurea-induced rat mammary tumours
| Autor: | Staab Hj, Hauff P, Arnold W, Winterfeld G, Iduna Fichtner, Görlich M |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
medicine.medical_specialty Ovariectomy medicine.medical_treatment Mammary gland Antineoplastic Agents Biology Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals skin and connective tissue diseases Chemotherapy Body Weight Estrogen Antagonists Mammary Neoplasms Experimental Methylnitrosourea General Medicine Antiestrogen Rats Tamoxifen Endocrinology medicine.anatomical_structure Castration Oncology chemistry Ovariectomized rat Female Aminoglutethimide Hormone medicine.drug |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 119:91-96 |
| ISSN: | 1432-1335 0171-5216 |
| Popis: | The effect of droloxifene, a new anti-oestrogenic drug, on N-nitrosomethylurea-induced mammary tumours of Sprague-Dawley rats was investigated and compared with that of tamoxifen. The response of tumour growth to ovariectomy or to treatment with aminoglutethimide or high doses of oestradiol was also studied. Ovariectomy was by far the most effective treatment for mammary-tumour-bearing animals. More than 75% of the tumours in ovariectomized rats did not grow progressively but remained in remission for up to 12 weeks after castration when the experiment was terminated. The inhibitory effects of droloxifene and tamoxifen on mammary tumour growth were similar, but body weight loss of animals treated with tamoxifen was more marked than that of animals treated with droloxifene at the same dose and schedule. |
| Databáze: | OpenAIRE |
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