CD34+ immune suppressive cells in the peripheral blood of patients with head and neck cancer
| Autor: | Young Mr, Beal Nm, Lathers Dm, Garrity T, Pandit R |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
T-Lymphocytes
CD34 Antigens CD34 Flow cytometry Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans 030223 otorhinolaryngology Blood Cells medicine.diagnostic_test business.industry Head and neck cancer Cancer General Medicine medicine.disease Head and neck squamous-cell carcinoma Blood Cell Count Otorhinolaryngology Epidermoid carcinoma Head and Neck Neoplasms 030220 oncology & carcinogenesis Immune System Immunology Blood Component Removal Carcinoma Squamous Cell business |
| Zdroj: | The Annals of otology, rhinology, and laryngology. 109(8 Pt 1) |
| ISSN: | 0003-4894 |
| Popis: | Patients with head and neck squamous cell carcinoma (HNSCC) have profound defects in their immune defenses. Using immu-nofluorescent staining and flow cytometric analysis, we found that most patients with HNSCC have increased levels of CD34+ cells within their peripheral blood. These circulating CD34+ cells contribute to the depressed functional competence of the peripheral blood T-lymphocytes. This was demonstrated by the increased level of proliferative responsiveness to interleukin-2 by the patients' peripheral blood T-cells after depletion of CD34+ cells. These results show the importance of CD34+ cells in contributing to the depression of T-lymphocyte function in patients with HNSCC and suggest that strategies designed to reduce the levels of circulating CD34+ cells may enhance the immune reactivity of the patients' circulating T-lymphocytes against the HNSCC. |
| Databáze: | OpenAIRE |
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