Central orexin facilitates gastric relaxation and contractility in rats
| Autor: | Ryuji Matsuo, Motoi Kobashi, Takashi Yamamoto, Yuichi Furudono |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Muscle Relaxation Gastric motility Neuropeptide Motility Vagotomy Biology Muscle Smooth Vascular Rats Sprague-Dawley Contractility Internal medicine mental disorders Pressure medicine Animals Orexins Relaxation (psychology) General Neuroscience Stomach Neuropeptides digestive oral and skin physiology Intracellular Signaling Peptides and Proteins Rats Orexin Endocrinology medicine.anatomical_structure nervous system Carrier Proteins Gastrointestinal Motility Distal stomach Muscle Contraction |
| Zdroj: | Neuroscience Letters. 332:171-174 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(02)00958-8 |
| Popis: | The effects of the intracisternal administration of synthetic orexin-A (3 nmol) on gastric motility were examined in rats. The administration of orexin but not a vehicle induced relaxation of the proximal stomach lasting for more than 30 min. Phasic contractions in the distal stomach were facilitated in response to the administration of orexin but not a vehicle. Facilitation in the distal stomach was not observed in the animals which underwent the sectioning of the bilateral vagi at the subdiaphragmatic level. Relaxation of the proximal stomach was observed in vagotomized animals but the magnitude of relaxation was significantly smaller than that in intact animals. These results suggest that central orexin facilitates distal stomach motility and relaxation of the proximal stomach via vagi. |
| Databáze: | OpenAIRE |
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