Evaluation of microRNA-155 as a diagnostic serum-based biomarker in patients with breast cancer
| Autor: | Salama Abd-Allatif, Amany H. Abdelrahman, Nagwa Abd-Elghaffar, Zahraa I Aboafya, Ingy Ashmawy, Elham Metawae, Eman A. Elghoroury, Nader Abd-Alhamid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty microrna-155 business.industry Mortality rate Cancer General Medicine medicine.disease RC31-1245 Real-time polymerase chain reaction Breast cancer breast cancer Internal medicine microRNA Gene expression medicine Biomarker (medicine) In patient business early diagnosis of breast cancer |
| Zdroj: | Al-Azhar Assiut Medical Journal, Vol 16, Iss 1, Pp 81-86 (2018) |
| ISSN: | 1687-1693 |
| Popis: | Background Breast cancer (BC) is the most common cancer among Egyptian women, and its early detection is accompanied with decreased mortality rates. MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression and affect cancer development. The expression level of miRNA-155 is up-regulated in BC and correlates with its invasive properties, offering a great potential as a noninvasive biomarker for BC screening. Objective The aim of this study is to evaluate the role of miRNA-155 as an early diagnostic serum-based biomarker of BC. Patients and methods This study was conducted on 30 patients newly diagnosed with BC and associated 20 healthy women as a control group. Serum level of miRNA-155 was measured for all studied cases using real-time quantitative PCR technique. Results MiRNA-155 expression was up-regulated in serum of patients with BC compared with control group (P |
| Databáze: | OpenAIRE |
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