Conditioning method determines patterns of c-fos expression following novel taste-illness pairing
| Autor: | Ilene L. Bernstein, Emily E. Wilkins |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Taste Central nervous system Administration Oral Drinking Behavior Insular cortex c-Fos Amygdala Lesion Behavioral Neuroscience Conditioning Psychological Neural Pathways Avoidance Learning Solitary Nucleus medicine Animals Rats Long-Evans Tissue Distribution Cerebral Cortex biology Solitary tract Association Learning Rats medicine.anatomical_structure Taste aversion biology.protein medicine.symptom Lithium Chloride Psychology Proto-Oncogene Proteins c-fos Neuroscience Behavioral Research |
| Zdroj: | Behavioural Brain Research. 169:93-97 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2005.12.006 |
| Popis: | Conditioned taste aversions (CTAs) can be established by exposing rats to a novel taste CS through a bottle or through intra-oral (IO) infusion. Lesion studies suggest differences between the two methods in their engagement of brain circuits, as excitotoxic amygdala lesions have no effect on bottle-conditioned CTAs, but eliminate CTAs produced using IO infusion. Fos-like immunoreactivity (FLI) was used to compare patterns of brain activation after pairing CS taste and US drug using bottle and IO methods. Conditioning rats using the bottle method was associated with widespread elevations in FLI throughout the putative CTA circuit (basolateral and central nuclei of amygdala, insular cortex and nucleus of the solitary tract). In contrast, IO conditioning led to activation only in the central nucleus of amygdala. This supports the suggestion of differences in aversion processing as a function of conditioning method and may explain the greater reliance on amygdala of IO-conditioned CTAs due to engagement of a less distributed neural network. |
| Databáze: | OpenAIRE |
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