Michaelis--Menten kinetic parameters of renal tubular secretion of para-alkylated mandelic acids and their use in revealing possible chemical characteristics around receptor site of secretion carrier in rats
| Autor: | Moiz A. Khambati, Janardan B. Nagwekar, Pravin M. Patel |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Chromatography
Gas Alkylation Chemical Phenomena Stereochemistry Pharmaceutical Science Michaelis–Menten kinetics Homologous series chemistry.chemical_compound Structure-Activity Relationship Isomerism Animals Secretion Receptor Alkyl chemistry.chemical_classification Binding Sites biology Mandelic acid Rats Chemistry Kinetics Kidney Tubules chemistry biology.protein Mandelic Acids Dialysis Organic anion Glomerular Filtration Rate |
| Zdroj: | Journal of pharmaceutical sciences. 62(7) |
| ISSN: | 0022-3549 |
| Popis: | From the determination of the Michaelis-Menten kinetic parameters (Vm and Km) of renal tubular secretion of D-(—)-p-n-propylmandelic acid (V) and D-(—)-p-isopropylmandelic acid (VI) in rats, it is shown that these compounds involve the same renal tubular carrier for their secretion but the affinity of V for the carrier is approximately twice that of VI. By considering these parameters as well as the structural variations of V and VI, together with those of other homologs of D-(—)-mandelic acid (I) studied previously, inferences have been drawn regarding the chemical nature around the possible cationic receptor site of the carrier for renal tubular secretion of organic anions in rats. The utilization of the model compounds of a homologous series of I in studying the influence of alkyl groups present in the organic anions on the pharmacokinetic parameters, particularly the volume of distribution, is discussed. |
| Databáze: | OpenAIRE |
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