Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2
| Autor: | Szilárd Szőcs, Tamas Lukacsovich, Natalia Andrea Cruz-Ochoa, Jochen Winterer, David P. Wolfer, Csaba Földy, Matteo Egger, David Lukacsovich, Andor Domonkos, Lin Que, Wenshu Luo, János Szabadics, Irmgard Amrein, Charlotte Seng, Antónia Arszovszki, Eszter Sipos, Csaba Varga |
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| Přispěvatelé: | University of Zurich, Földy, Csaba |
| Rok vydání: | 2021 |
| Předmět: |
Mossy fiber (hippocampus)
single-cell RNA-Seq Transcription Genetic 10017 Institute of Anatomy Neurogenesis education Central nervous system mossy fiber Id2 circuit formation adult brain rewiring 610 Medicine & health Biology Mice 03 medical and health sciences 0302 clinical medicine medicine Transcriptional regulation Animals Inhibitor of Differentiation Protein 2 030304 developmental biology Hippocampal mossy fiber 1000 Multidisciplinary 0303 health sciences Multidisciplinary 10242 Brain Research Institute Biological Sciences Rats medicine.anatomical_structure Epilepsy Temporal Lobe Mossy Fibers Hippocampal 570 Life sciences biology Spatial cues Ectopic expression Neuroscience 030217 neurology & neurosurgery Sprouting |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, 118 (40) Proceedings of the National Academy of Sciences of the United States of America |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits. We found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fiber sprouting in healthy adult mouse and rat. Mice with the new mossy fiber circuit solved spatial problems equally well as controls but appeared to rely on local rather than global spatial cues. Our results demonstrate reprogrammed connectivity in mature neurons by one defined factor and an assembly of a new synaptic circuit in adult brain. Proceedings of the National Academy of Sciences of the United States of America, 118 (40) ISSN:0027-8424 ISSN:1091-6490 |
| Databáze: | OpenAIRE |
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