Entecavir for the treatment of real-life chronic hepatitis B patients: a study from Saudi Arabia
| Autor: | Mohammed Alquaiz, Saleim Towfeig Dahab, Musthafa Chalikandy Peedikayil, Hamad Ibrahim Al-Ashqar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male endocrine system Pediatrics medicine.medical_specialty Hepatitis B virus Guanine genetic structures Treatment outcome Population Saudi Arabia lcsh:Medicine Antiviral Agents Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Chronic hepatitis medicine Humans 030212 general & internal medicine Hepatitis B e Antigens education Retrospective Studies education.field_of_study business.industry lcsh:R Follow up studies virus diseases Retrospective cohort study General Medicine Entecavir Hepatitis B Middle Aged Viral Load medicine.disease digestive system diseases Treatment Outcome DNA Viral 030211 gastroenterology & hepatology Female business Viral load Biomarkers medicine.drug Follow-Up Studies |
| Zdroj: | Annals of Saudi Medicine, Vol 33, Iss 2, Pp 119-123 (2013) |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.5144/0256-4947.2013.119 |
| Popis: | BACKGROUND AND OBJECTIVES: Entecavir is a nucleoside analog used in the treatment of chronic hepatitis B. The efficacy of ETV has not been studied in the Saudi population. The objective of the study was to find undetectable HBV DNA after 48 weeks completion of ETV treatment in real-life versus clinical trial patients. DESIGN AND SETTING: A retrospective study in a tertiary care center in Saudi Arabia of patients treated from 2006 January to 2010 June. PATIENTS AND METHODS: Of 43 eligible patients, 24 patients were treatment-naïve and 19 were treatment refractory. RESULTS: Mean HBV DNA viral load was 51 million IU/mL prior to treatment and decreased to 0.16 million IU/mL at 48 weeks. Mean HBV DNA log10 IU/mL was 6.3 before treatment and decreased to 2.3 log10 IU/mL (P=.001) at 48 weeks. After 48 weeks treatment, ALT significantly decreased from a mean ALT of 88.7 U/L before treatment to 37.5U/L (P=.04). After 48 weeks, the HBV DNA was undetectable in 14 (58.4%) in treatment-naïve patients and in 6 (31.6%) treatment-refractory patients. At 48 weeks 17 (60.7%) of HBeAg-negative patients and 3 (20%) HBeAg-positive patients achieved undetectable HBV DNA (P=.003). When the treatment was extended for a median of 24 months (range 12 months to 60 months), 29 (67.4%) achieved undetectable HBV DNA. Among 29 patients who achieved undetectable HBV DNA, the treatment refractory patients reached undetectability within a mean of 32.4 (18.6) months and treatment-naïve patients in a mean of 18.8 (10.5) months (P=.01). Two (13.3%) of HBeAg-reactive patients converted to HBeAg-negative status and one patient (2.3%) lost HBsAg. CONCLUSION: After treatment with entecavir, HBV DNA undetectable at 48 weeks in 58.4% of naïve patients. The response rate was better in HBeAg-negative and treatment-naïve patients compared to HBeAg-positive and treatment-refractory patients. |
| Databáze: | OpenAIRE |
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