Evolution and diversification of the nuclear pore complex
| Autor: | Mark C. Field, Alexandr A. Makarov, Norma E Padilla-Mejia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Bioinformatics
Mitosis Context (language use) Biochemistry 03 medical and health sciences 0302 clinical medicine Intraflagellar transport otorhinolaryngologic diseases Animals RNA Messenger Nuclear pore Nucleomorph Review Articles 030304 developmental biology Evolutionary Biology 0303 health sciences Nucleoplasm biology nuclear pores Membrane Proteins Biological Transport eukaryogenesis biology.organism_classification Biological Evolution nuclear protein transport stomatognathic diseases Cytoplasm Evolutionary biology Cell Cycle Growth & Proliferation Nuclear Pore Eukaryote Adaptation 030217 neurology & neurosurgery |
| Zdroj: | Biochemical Society Transactions |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst20200570 |
| Popis: | The nuclear pore complex (NPC) is responsible for transport between the cytoplasm and nucleoplasm and one of the more intricate structures of eukaryotic cells. Typically composed of over 300 polypeptides, the NPC shares evolutionary origins with endo-membrane and intraflagellar transport system complexes. The modern NPC was fully established by the time of the last eukaryotic common ancestor and, hence, prior to eukaryote diversification. Despite the complexity, the NPC structure is surprisingly flexible with considerable variation between lineages. Here, we review diversification of the NPC in major taxa in view of recent advances in genomic and structural characterisation of plant, protist and nucleomorph NPCs and discuss the implications for NPC evolution. Furthermore, we highlight these changes in the context of mRNA export and consider how this process may have influenced NPC diversity. We reveal the NPC as a platform for continual evolution and adaptation. |
| Databáze: | OpenAIRE |
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