E-Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells

Autor:	Jacqueline B Tiley, Kim L. R. Brouwer, Henry Ho, Brittany P. Rickard, Ilona Jaspers
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Chemistry General Chemical Engineering Vanillin Liver cell Isoamyl acetate Ethyl maltol General Chemistry Pharmacology Article chemistry.chemical_compound Hepg2 cells Toxicity Viability assay Cytotoxicity QD1-999
Zdroj:	ACS Omega ACS Omega, Vol 6, Iss 10, Pp 6708-6713 (2021)
ISSN:	2470-1343
Popis:	E-cigarette-related hospitalizations and deaths across the U.S. continue to increase. A high percentage of patients have elevated liver function tests indicative of systemic toxicity. This study was designed to determine the effect of e-cigarette chemicals on liver cell toxicity. HepG2 cells were exposed to flavoring chemicals (isoamyl acetate, vanillin, ethyl vanillin, ethyl maltol, l-menthol, and trans-cinnamaldehyde), propylene glycol, and vegetable glycerin mixtures, and cell viability was measured. Data revealed that vanillin, ethyl vanillin, and ethyl maltol decreased HepG2 cell viability; repeated exposure caused increased cytotoxicity relative to single exposure, consistent with the hypothesis that frequent vaping can cause hepatotoxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dfece8be7992a2dd13db8728ed5d25 http://europepmc.org/articles/PMC7970492 Zobrazit plný text záznamu