Epstein-Barr Virus Encodes a Novel Homolog of the bcl-2 Oncogene That Inhibits Apoptosis and Associates with Bax and Bak
| Autor: | Ching Yim, Joyce D. Fingeroth, David R. Sage, Robert W. Finberg, William L. Marshall, Erik Gustafson, Louisa Williams, Thomas Graf, Katherine Hanify |
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| Rok vydání: | 1999 |
| Předmět: |
Herpesvirus 4
Human viruses Molecular Sequence Data Immunology bcl-X Protein Apoptosis medicine.disease_cause Microbiology Virus Open Reading Frames Bcl-2-associated X protein hemic and lymphatic diseases Proto-Oncogene Proteins Virology Complementary DNA medicine Amino Acid Sequence bcl-2-Associated X Protein biology Membrane Proteins Transfection Epstein–Barr virus Fusion protein Molecular biology Genes bcl-2 Virus-Cell Interactions Open reading frame bcl-2 Homologous Antagonist-Killer Protein Proto-Oncogene Proteins c-bcl-2 Insect Science biology.protein Bcl-2 Homologous Antagonist-Killer Protein |
| Zdroj: | Journal of Virology. 73:5181-5185 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | The sequenced gammaherpesviruses each contain a single viral bcl-2 homolog (v- bcl-2 ) which may encode a protein that functions in preventing the apoptotic death of virus-infected cells. Epstein-Barr virus (EBV), a gammaherpesvirus associated with several lymphoid and epithelial malignancies, encodes the v-Bcl-2 homolog BHRF1. In this report the previously uncharacterized BALF1 open reading frame in EBV is identified as having significant sequence similarity to other v- bcl-2 homologs and cellular bcl-2 . Transfection of cells with a BALF1 cDNA conferred apoptosis resistance. Furthermore, a recombinant green fluorescent protein-BALF1 fusion protein suppressed apoptosis and associated with Bax and Bak. These results indicate that EBV encodes a second functional v- bcl-2 . |
| Databáze: | OpenAIRE |
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