A new type of acyclic, achiral nucleoside analogue. How does it simulate nucleosides?

Autor:	Thomas Boesen, Otto Dahl, Asger B. Petersen
Rok vydání:	2003
Předmět:	chemistry.chemical_classification Models Molecular Guanine Double bond Nucleoside analogue Rotation Stereochemistry Molecular Conformation Nucleosides General Medicine Biochemistry Molecular conformation Nucleobase chemistry.chemical_compound Monomer chemistry Isomerism Genetics medicine Molecular Medicine Free rotation medicine.drug Envelope (waves)
Zdroj:	Nucleosides, nucleotidesnucleic acids. 22(5-8)
ISSN:	1525-7770
Popis:	The new monomer 1 seems to be an excellent mimic of nucleosides with different sugar conformations (north, south, and envelope), because of the relatively free rotation around gamma, delta, and chi. The rotation around chi is primarily controlled by the repulsion between H6 and the two hydrogen atoms on C4' and not pi conjugation between the double bond and the nucleobase. A viable synthesis of the guanine monomer 8 is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dd4ea9daad8178a636b2fa2aa60ecf https://pubmed.ncbi.nlm.nih.gov/14565265 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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