The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers
| Autor: | Yesim Ozdemir, Murat Cag, Emel Colak, Nuriye Coskun, Neslihan Basgoz, Hakan Sarici, Dilek Kaan, Muhammet Dogan, Kemal Deniz, Mevlude Inanc, Yusuf Ozkul |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Genes APC Adolescent High-Throughput Nucleotide Sequencing General Medicine Middle Aged Genes p53 Survival Analysis DNA Glycosylases Young Adult Case-Control Studies Colonic Neoplasms Mutation Humans Female Genetic Predisposition to Disease Neoplasm Metastasis Germ-Line Mutation Aged Retrospective Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 22(12) |
| ISSN: | 2476-762X |
| Popis: | It is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers.A total of 50 patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 were included in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53, PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next generation sequencing method. The effect of gene mutations on metastasis and overall survival were evaluated.The mean age of patients with colon cancer without distant metastasis was 48.64±14.72 years and for patients with distance metases was 56.68±11.65. The mean survival time of colon cancer patients with distant organ metastasis after the metastasis date was 104.36±58.59 weeks. The presence of APC, MUTYH, and TP53 genetic mutations was observed with a higher rate in metastatic colon cancer (p0.05).We showed that APC, MUTYH, and TP53 mutations are associated with distant organ metastasis. |
| Databáze: | OpenAIRE |
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