Effect of Different 131I Dose Strategies for Treatment of Hyperthyroidism on Graves' Ophthalmopathy
| Autor: | Narjess Ayati, Seyed Rasoul Zakavi, Shahrara Ariamanesh, Zohreh Mousavi, Zahra Mazloum Khorasani, Zahra Kiamanesh, Victoria Kiavash |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity Thyroid Gland Physical examination Radiation Dosage Thyroid function tests Gastroenterology 030218 nuclear medicine & medical imaging law.invention Graves' ophthalmopathy Iodine Radioisotopes 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Snellen chart medicine.diagnostic_test business.industry Thyroid Radiotherapy Dosage General Medicine Middle Aged medicine.disease Graves Disease medicine.anatomical_structure 030220 oncology & carcinogenesis Female medicine.symptom business |
| Zdroj: | Clinical nuclear medicine. 45(7) |
| ISSN: | 1536-0229 |
| Popis: | PURPOSE The study aims to define the effect of different dose strategies on ophthalmic complications in patients with Graves' disease (GD). METHODS All the patients with GD and no or inactive ophthalmopathy (clinical activity score; CAS < 3) underwent Snellen chart examination, measurement of proptosis, thyroid volume, and radioactive iodine uptake, and randomized into 1 of 3 groups. In group 1, all the patients received fixed low dose (FLD) of 259 MBq of I, whereas in group 2, all the patients received fixed high dose (FHD) of 555 MBq, and in group 3, calculated dose (CD) was administered to deliver 5.55 MBq/g (thyroid weight) of I. All examinations were repeated 6 months after treatment. The measurement of thyroid function tests and clinical examination were repeated after 12 months. RESULTS We studied 92 patients (58 female and 34 male) with mean age of 38.2 ± 12.0 years. Overall, 29, 32, and 31 patients were studied in FLD, FHD, and CD groups, respectively. The patients in CD received a mean activity of 240.5 MBq. The 3 groups were not significantly different regarding age, sex ratio, radioactive iodine uptake, smoking, visual acuity, and proptosis. The response rate 12 months after radioactive iodine therapy was 66.7%, 94.4%, and 92.9% in FLD, FHD, and CD groups, respectively (P = 0.05). Overall, CAS was increased significantly after treatment. Delta proptosis and delta CAS were increased significantly in FHD group compared with other groups (P < 0.05). The highest increment in proptosis was seen in FHD group. CONCLUSIONS The administration of 5.55 MBq/g of I has fewer ophthalmic complications compared with high fixed dose model and is more effective than low fixed dose strategy. |
| Databáze: | OpenAIRE |
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