Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil
| Autor: | Regina Maria Bringel Martins, Aline Garcia Kozlowski, Sheila Araújo Teles, Renata Ferreira, Nadia R. S. Reis, Megmar Aparecida dos Santos Carneiro, Clara F. T. Yoshida, Silvia M. Botelho |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male hepatitis C virus Microbiology (medical) medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine Adolescent Genotype ALT lcsh:RC955-962 Hepatitis C virus medicine.medical_treatment prevalence Population lcsh:QR1-502 Hepacivirus medicine.disease_cause lcsh:Microbiology renal transplant recipients genotypes Internal medicine Epidemiology medicine Humans risk factors Infection control Risk factor education Aged education.field_of_study business.industry virus diseases Alanine Transaminase Hepatitis C Antibodies Middle Aged Hepatitis C Kidney Transplantation digestive system diseases Transplantation Immunology Kidney Failure Chronic RNA Viral Female Hemodialysis business Brazil |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 103, Iss 5, Pp 472-476 (2008) Memórias do Instituto Oswaldo Cruz, Volume: 103, Issue: 5, Pages: 472-476, Published: AUG 2008 |
| ISSN: | 0074-0276 |
| DOI: | 10.1590/s0074-02762008000500011 |
| Popis: | An investigation was conducted involving 255 renal transplant recipients in the state of Goiás, Central Brazil, to determine the prevalence of hepatitis C virus (HCV), its risk factors, the genotypes involved, and the level of alanine aminotransferase (ALT) present in the patients. All serum samples were tested for anti-HCV antibodies and HCV RNA. Forty-one patients were anti-HCV and/or HCV RNA positive, resulting in an overall HCV infection prevalence of 16.1% (95% CI: 11.9-21.3). A multivariate analysis of risk factors showed that a history of blood transfusions without anti-HCV screening, the length of time spent on hemodialysis, and renal transplantation before 1994 are all associated with HCV positivity. In HCV-positive patients, only 12.2% had ALT levels above normal. Twenty-eight samples were genotyped as genotype 1, subtypes 1a (62.5%) and 1b (31.3%), and two samples (6.2%) were genotype 3, subtype 3a. These data show a high prevalence of HCV infection and low ALT levels in the studied population. The risk factor analysis findings emphasize the importance of public health strategies such as anti-HCV screening of candidate blood and organ donors, in addition to the stricter adoption of hemodialysis-specific infection control measures. The present study also demonstrates that HCV genotype 1 (subtype 1a) is predominant in this population. |
| Databáze: | OpenAIRE |
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