The prevalence and demographic features of congenital cytomegalovirus infection in an urban area of East Asia: A population-based study

Autor: Chuan-Jen Hsu, Hung-Meng Huang, Wei-Chung Hsu, Po-Nien Tsao, Tien-Chen Liu, Chuan Song Wu, Shih-Ming Weng, Li-Min Huang, Tzong-Hann Yang, Chun-Yi Lu, Chen-Chi Wu
Rok vydání: 2020
Předmět:
Cytomegalovirus Infection
Pediatrics
Viral Diseases
Urban Population
Maternal Health
Geographical Locations
Families
Labor and Delivery
0302 clinical medicine
Medical Conditions
Hearing
Pregnancy
Prevalence
Medicine and Health Sciences
Medicine
030212 general & internal medicine
Fertility Rates
Children
education.field_of_study
Multidisciplinary
Asia
Eastern
Obstetrics and Gynecology
Infectious Diseases
Cytomegalovirus Infections
Female
medicine.symptom
Pediatric Infections
Infants
Research Article
medicine.medical_specialty
Asia
Total fertility rate
Science
Population
Congenital cytomegalovirus infection
Taiwan
Asymptomatic
Hearing screening
03 medical and health sciences
Neonatal Screening
Population Metrics
030225 pediatrics
Statistical significance
Humans
education
Population Biology
business.industry
Public health
Infant
Newborn
Biology and Life Sciences
Neonates
medicine.disease
Population based study
Age Groups
People and Places
Birth
Women's Health
Population Groupings
business
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0248801 (2021)
ISSN: 1932-6203
Popis: Congenital cytomegalovirus (cCMV) infection is the leading environmental cause of childhood hearing impairment. However, its significance remains largely undocumented in many regions of the world. The purpose of this study was to investigate the prevalence and clinical features of cCMV infection in East Asia. Neonates born at a municipal hospital in Taipei were prospectively recruited and underwent concurrent hearing and CMV screenings. Those who failed the hearing screening or screened positive for CMV were subjected to a focused audiological and/or virological surveillance. The characteristics of the newborns and their mothers were compared between the CMV-positive and CMV-negative groups. Of the 1,532 newborns who underwent concurrent hearing and CMV screenings, seven (0.46%) were positive for cCMV infection. All seven CMV-positive newborns were asymptomatic at birth, and none of them developed hearing or other symptoms during a follow-up period of 14.4±6.3 months. The mothers of the CMV-positive newborns demonstrated higher gravidity (2.4 ± 1.4 vs. 2.1 ± 1.2) and parity (2.0 ± 1.2 vs. 1.6 ± 0.7) than those in the CMV-negative group; however, the difference did not reach statistical significance. The prevalence of cCMV infection in Taipei newborns was 0.46%, which is slightly lower than that of other populations and that of a previous report in the Taiwanese population. The relatively low prevalence in this study might be attributed to the improved public health system and decreased fertility rate in Taiwan.
Databáze: OpenAIRE
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