Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis

Autor: Brunno Felipe Ramos Caetano, Cláudio Cabello, Nelci Antunes de Moura, Maria Aparecida Marchesan Rodrigues, Luis Fernando Barbisan, Katia Sivieri, Luis H. Urbano
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2013-09-27T14:53:40Z (GMT). No. of bitstreams: 1 WOS000308255800044.pdf: 1580128 bytes, checksum: 0e220db38c6bb64ccb519aeb1bfe707b (MD5) Previous issue date: 2012-08-01 Made available in DSpace on 2013-09-30T18:39:59Z (GMT). No. of bitstreams: 1 WOS000308255800044.pdf: 1580128 bytes, checksum: 0e220db38c6bb64ccb519aeb1bfe707b (MD5) Previous issue date: 2012-08-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:52:35Z No. of bitstreams: 1 WOS000308255800044.pdf: 1580128 bytes, checksum: 0e220db38c6bb64ccb519aeb1bfe707b (MD5) Made available in DSpace on 2014-05-20T13:52:35Z (GMT). No. of bitstreams: 1 WOS000308255800044.pdf: 1580128 bytes, checksum: 0e220db38c6bb64ccb519aeb1bfe707b (MD5) Previous issue date: 2012-08-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH-initiation, groups were fed basal diet (Cl and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5 x 10(10) CFU per g diet) for 13 weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower in the group fed synbiotic formulation (p < 0.02). A significant reduction in cell proliferation in colonic crypts and tumors and short chain fatty acids (SCFA) caecal contents was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4). Therefore, the findings this study indicate that yacon and yacon plus L casei intake may reduce the development of chemically-induced colon cancer. (C) 2012 Elsevier Ltd. All rights reserved. UNESP São Paulo State Univ, Inst Biosci, Program Postgrad, Gen & Appl Biol Program, BR-18618970 Botucatu, SP, Brazil UNESP São Paulo State Univ, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil UNESP São Paulo State Univ, Sch Pharmaceut Sci, Dept Food & Nutr, BR-14801902 Araraquara, SP, Brazil UNESP São Paulo State Univ, Sch Agron Sci, CERAT, BR-18610307 Botucatu, SP, Brazil UNESP São Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP, Brazil UNESP São Paulo State Univ, Inst Biosci, Program Postgrad, Gen & Appl Biol Program, BR-18618970 Botucatu, SP, Brazil UNESP São Paulo State Univ, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil UNESP São Paulo State Univ, Sch Pharmaceut Sci, Dept Food & Nutr, BR-14801902 Araraquara, SP, Brazil UNESP São Paulo State Univ, Sch Agron Sci, CERAT, BR-18610307 Botucatu, SP, Brazil UNESP São Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP, Brazil FAPESP: 09/12239-2 FAPESP: 11/01126-2 CNPq: 301585/2009-1
Databáze: OpenAIRE
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