Serum DHEA-S, Testosterone and Cortisol Levels in Female Patients with Schizophrenia
| Autor: | Ayse Gokcen Gundogmus, Süheyla Doğan Bulut, Çiğdem Aydemir, Serdar Bulut |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Olanzapine Hydrocortisone Endocrinology Diabetes and Metabolism Physiology Severity of Illness Index Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Humans Immunology and Allergy Medicine Testosterone Scale for the Assessment of Negative Symptoms Biologic marker Dehydroepiandrosterone Sulfate business.industry Age Factors Middle Aged medicine.disease Pathophysiology 030227 psychiatry Premenopause Schizophrenia Case-Control Studies Quetiapine Female Schizophrenic Psychology business Biomarkers 030217 neurology & neurosurgery medicine.drug Hormone |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 18:348-354 |
| ISSN: | 1871-5303 |
| DOI: | 10.2174/1871530318666180212102128 |
| Popis: | Objective To compare the relation symptom severity and testosterone levels, and DHEA-S and cortisol in premenopausal women with schizophrenia and an age- and sex-matched control group. Methods Thirty-two women with schizophrenia and 32 age- and sex-matched healthy controls were included in the study. All participants were aged between 20 and 45 years, and their previous treatments were olanzapine (n=14) and quetiapine (n=18). Symptom severity was assessed using the Scale for the Assessment of Positive Symptoms (SAPS) and Scale for the Assessment of Negative Symptoms (SANS). A chemiluminescence immunoassay was used to investigate hormone profiles of the two groups, which were then compared and analyzed. The relation between the hormone levels and SANS and SAPS scores of the study group and controls was examined. Results There were statistically significantly higher levels of serum DHEA-S (p=0.002) in the study group than in the control group. No statistically significant difference was determined between the groups regarding serum testosterone and cortisol levels. A positive correlation was determined between the study groups' SANS scores and DHEA-S levels (p=0.012, r=0.440). Conclusion DHEA-S might be a potential biologic marker for schizophrenia because there is evidence of an association between DHEA-S and the pathophysiology of schizophrenia. However, further research with greater patient numbers is required to verify these findings. |
| Databáze: | OpenAIRE |
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