Do patients with bipolar disorder and subsyndromal symptoms benefit from functional remediation? A 12-month follow-up study
| Autor: | Ramón Landin-Romero, ANGELA IBAÑEZ, Marta Rapado-Castro, Patricia Correa Ghisays, Celso Arango, Vicent Balanzá-Martínez, Ana María González-Pinto, Barbara Segura, Jose Menchon, Inmaculada Fuentes Durá, ESTHER JIMENEZ, Benedikt L Amann, Pilar A. Saiz, Rafael Tabares-Seisdedos, Jose Luis Ayuso-Mateos, Anabel Martinez-Aran, Adriane Rosa, Caterina del Mar Bonnín, Paz Garcia-Portilla, Jose Sanchez-Moreno, Julio Bobes, Brisa Solé, CRISTINA VARO, Eduard Vieta, Sara Barbeito Resa, Silvia Alonso-Lana |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder medicine.medical_treatment Young Mania Rating Scale law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Rating scale law mental disorders medicine Psychoeducation Humans Pharmacology (medical) Bipolar disorder Biological Psychiatry Depression (differential diagnoses) Psychiatric Status Rating Scales Pharmacology Analysis of Variance Chi-Square Distribution Middle Aged medicine.disease Cognitive Remediation 030227 psychiatry Psychotherapy Psychiatry and Mental health Treatment Outcome Mood Neurology Physical therapy Female Neurology (clinical) Psychology Psychosocial 030217 neurology & neurosurgery Follow-Up Studies Clinical psychology |
| Zdroj: | European Neuropsychopharmacology. 27:350-359 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2017.01.010 |
| Popis: | We analyzed the efficacy of functional remediation, in a sample of patients with bipolar disorder who presented with subsyndromal symptoms. From a total sample of 239 patients with bipolar I and II disorder, according to DSM-IV-TR diagnostic criteria, entering a randomized clinical trial, those patients who presented with subsyndromal symptoms were selected based on a method already described by Berk and colleagues was applied. It consists of using the Clinical Global Impression-Bipolar version (CGI-BP) to establish the scores of the Hamilton Depression Rating Scale (HAM-D) and of the Young Mania Rating Scale (YMRS) that correspond with 1 in the CGI-BP. Functional outcome and mood symptoms were assessed at 6 and at 12-month follow-up. A total of 99 patients were selected for this post-hoc analysis, allocated as follows: functional remediation (n=33); psychoeducation (n=37) and treatment as usual (TAU,n=29). The repeated-measures analyses at 12-month follow-up revealed a significant group x time interaction in favour of the patients who received functional remediation when compared to psychoeducation and TAU (F=2.93; p=0.02) at improving psychosocial functioning. Finally, mood symptoms did not significantly change in any of the three groups at any time of follow-up, as shown by the non-significant group x time interaction effect in HAM-D scores (F=1.57; p=0.18) and YMRS scores (F=1.51; p=0.20). Bipolar patients with subsyndromal symptoms improve their functional outcome when exposed to functional remediation regardless of the persistence of mood symptomatology. |
| Databáze: | OpenAIRE |
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