Mortality from cancer and other causes among Italian chrysotile asbestos miners
| Autor: | Enrico Pira, Canzio Romano, Carlo La Vecchia, Claudio Pelucchi, Francesca De' Donato, Paolo Boffetta |
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| Přispěvatelé: | Pira, E. and Romano, C. and Donato, F. and Pelucchi, C. and Vecchia, C.L. and Boffetta, P. |
| Rok vydání: | 2017 |
| Předmět: |
Male
Mesothelioma Lung Neoplasms very elderly chrysotile Aged groups by age pleural cancer peritoneum cancer pharynx cancer Cumulative Exposure asbestosi medicine.disease_cause lung tumor Cohort Studies Toxicology violence 0302 clinical medicine Cause of Death Neoplasms cancer mortality Chrysotile 80 and over Poisson Distribution 030212 general & internal medicine Pleural Neoplasm Aged 80 and over sensitivity analysi Middle Aged 030210 environmental & occupational health cerebrovascular disease Occupational Diseases esophagus cancer priority journal Italy employment Cohort Pleural Cancer epidemiology Public Health Asbestos chrysotile lung cancer mining Aged Asbestos Serpentine Chronic Disease Environmental Monitoring Humans Mining Mortality Occupational Exposure Pleural Neoplasms Public Health Environmental and Occupational Health Human cohort analysi miner Article smoking pleura tumor 03 medical and health sciences adverse effect medicine follow up tuberculosi Lung cancer liver cirrhosi business.industry Serpentine Environmental and Occupational Health Mesothelioma Malignant pleura cancer larynx cancer Cancer accident mouth cancer medicine.disease ischemic heart disease major clinical study chrysotile asbestos miner Lung Neoplasm Occupational Disease Standardized mortality ratio Neoplasm Cohort Studie business chronic obstructive lung disease Demography |
| Zdroj: | Occupational and Environmental Medicine. 74:558-563 |
| ISSN: | 1470-7926 1351-0711 |
| Popis: | Objective To investigate the long-term mortality of a cohort of Italian asbestos miners. Methods The cohort included 1056 men employed in a chrysotile mine between 1930 and 1990, who were followed up during 1946-2014, for a total of 37 471 person-years of observation. Expected deaths and SMRs were computed using national and local (after 1980, when available) reference. Results A total of 294 (27.8%) subjects were alive and at the end of follow-up, 722 (68.4%) were dead and 40 (3.8%) were lost to follow-up. The SMR for overall mortality was 1.35 (95%CI 1.25 to 1.45). The SMR for pleural cancer, based on seven observed deaths, was 5.54 (95% CI 2.22 to 11.4) and related to time since first exposure, but not to duration of employment, cumulative exposure or time since last exposure. The SMR for lung cancer was 1.16 (95% CI 0.87 to 1.52; 53 observed deaths), with no excess among workers with cumulative exposure below 100 fibre/mL-years (SMR 0.82; 95% CI 0.44 to 1.40). Conclusions The update of the follow-up of this cohort confirmed an increased mortality from pleural cancer mortality in miners exposed to chrysotile and a lack of significant increase in lung cancer mortality. © Article author(s) 2017 (or their employer(s) unless otherwise stated in the text of the article). All rights reserved. No commercial use is permitted unless otherwise expressly granted. |
| Databáze: | OpenAIRE |
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