Increased C-Reactive Protein Levels in the Polycystic Ovary Syndrome: A Marker of Cardiovascular Disease
| Autor: | O Zinder, Yishai Levy, R. Leiba, R. Linn, Zeev Blumenfeld, N. Boulman, S. Shachar |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Biology Biochemistry Body Mass Index chemistry.chemical_compound Endocrinology Internal medicine White blood cell Diabetes mellitus medicine Humans Stroke Retrospective Studies Cholesterol Osmolar Concentration Biochemistry (medical) C-reactive protein Case-control study medicine.disease Polycystic ovary C-Reactive Protein Cross-Sectional Studies medicine.anatomical_structure chemistry Cardiovascular Diseases Case-Control Studies biology.protein Female Body mass index Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 89:2160-2165 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2003-031096 |
| Popis: | The polycystic ovary syndrome (PCOS), one of the most common reproductive abnormalities, shares some components of the metabolic cardiovascular syndrome. Therefore, PCOS patients may represent the largest group of women at high risk for the development of early-onset cardiovascular disease (CVD) and/or diabetes. C-reactive protein (CRP) is a strong independent predictor of future CVD and/or stroke. Only one small published study has looked for such an association (17 PCOS patients vs. 15 controls). The objective of this study was to compare the levels of CRP and other risk factors of CVD in a large group of PCOS patients and controls. CRP measurements were undertaken in 116 PCOS patients and 94 body mass index-matched controls with regular menstrual cycles. Whereas 36.8% of the PCOS patients had CRP levels above 5 mg/liter, only 9.6% of the controls exhibited high CRP levels (P < 0.001). The mean +/- SD was 5.46 +/- 7.0 in the PCOS group vs. 2.04 +/- 1.9 mg/liter in the control (P < 0.001). The body mass index, white blood cell count, TSH, glucose, cholesterol, and homocysteine levels were not significantly different between the two groups. CRP levels are elevated in patients with PCOS and may be a marker of early cardiovascular risk in these patients. High CRP levels may explain why some PCOS women may possibly be at an increased risk for the development of early-onset CVD. Consequently, whether treatment regimens directed toward lowering CVD risk factors should be more aggressive for those PCOS women with increased CRP levels, awaits further clinical experience. |
| Databáze: | OpenAIRE |
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