Genetic, host, and environmental interactions in a 19 year old with severe chronic obstructive lung disease; observations regarding the pathophysiology of airflow obstruction
| Autor: | Jonathan Killam, Edward Eden, James Lozada, Horiana Grosu, Andrew Needelman, Elvina Khusainova |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pathology Acute Lung Injury Case Report macromolecular substances Lung injury Severity of Illness Index Gastroenterology chronic obstructive pulmonary disease Pulmonary Disease Chronic Obstructive Young Adult Pregnancy alpha 1-Antitrypsin Deficiency Internal medicine bronchopulmonary dysplasia medicine Humans Diaphragmatic hernia Hernia Diaphragmatic alpha-1 antitrypsin deficiency COPD Lung Alpha 1-antitrypsin deficiency business.industry Environmental Exposure General Medicine Environmental exposure respiratory system medicine.disease Obstructive lung disease respiratory tract diseases medicine.anatomical_structure Bronchopulmonary dysplasia Prenatal Exposure Delayed Effects Swyer James Macleod syndrome Lung Hyperlucent Education Medical Continuing Female Gene-Environment Interaction Hernias Diaphragmatic Congenital business |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| DOI: | 10.2147/copd.s30325 |
| Popis: | A case of a 19-year-old with severe chronic obstructive pulmonary disease is presented. This case illustrates genetic (severe alpha-1 antitrypsin deficiency) and host factors (such as developmental diaphragmatic hernia and the innate response to injury), and environmental (high oxidative stress and lung injury) interactions that lead to severe chronic obstructive lung disease. The development of chronic lung disease was caused by lung injury under high oxidative and inflammatory conditions in the setting of a diaphragmatic hernia. In the absence of normal alpha-1 antitrypsin levels, a pro-elastolytic environment in the early period of lung growth enhanced the development of severe hyperinflation and precocious airflow obstruction. |
| Databáze: | OpenAIRE |
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