Percutaneous penetration of uranium in rats after a contamination on intact or wounded skin
| Autor: | François Paquet, C. Gautier, F. Petitot, Sandrine Frelon, A M. Moreels |
|---|---|
| Přispěvatelé: | Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), Institut de Radioprotection et de Sûreté Nucléaire (IRSN) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
radiation hazard Percutaneous [SDV]Life Sciences [q-bio] Excoriation Rats Hairless Chemical burn chemical burn Wounds Penetrating radiometry skin penetration Hairless 030218 nuclear medicine & medical imaging chemistry.chemical_compound 0302 clinical medicine Penetrating Models rat animal skin permeability Radiation Radiological and Ultrasound Technology integumentary system radiation absorption diffusion article methodology General Medicine simulation Foreign Bodies radioactive contamination nitric acid relative biologic effectiveness medicine.anatomical_structure 030220 oncology & carcinogenesis uranyl nitrate Wounds Body Burden Uranium hydrofluoric acid skin injury hairless rat medicine.medical_specialty Diet therapy Metabolic Clearance Rate Skin Absorption animal experiment Urology urinary excretion Models Biological penetrating trauma in vivo study 03 medical and health sciences In vivo medicine Stratum corneum physical chemistry computer simulation stratum corneum Animals Radiology Nuclear Medicine and imaging controlled study sodium hydroxide nonhuman animal model Public Health Environmental and Occupational Health medicine.disease biological model foreign body Biological occupational hazard Surgery Rats Kinetics Uranyl nitrate chemistry diet therapy metabolism Relative Biological Effectiveness |
| Zdroj: | RADIATION PROTECTION DOSIMETRY RADIATION PROTECTION DOSIMETRY, 2007, 127 (1-4), pp.125-130. ⟨10.1093/rpd/ncm261⟩ |
| DOI: | 10.1093/rpd/ncm261⟩ |
| Popis: | The aim of this work is to assess in vivo in a hairless rat model, the percutaneous diffusion of uranium through intact or wounded rat skin. Six types of wounds were simulated by excoriation and burns with 10 N HF, 2, 5 and 14 N HNO3 and 10 N NaOH on anaesthetised hairless rats. Percutaneous penetration through wounded skin towards blood and subsequent urinary excretion of uranium was followed in vivo during 24 h. The influence of the physicochemical form (solution or powder) of uranyl nitrate (UN) on its percutaneous diffusion was also investigated. UN, even as a powder, can diffuse through intact skin. The presence of uranium in blood is more persistent and its urinary elimination is slower after an HF burn than after an HNO3 burn. Excoriation increases dramatically percutaneous absorption of UN. Thus, percutaneous diffusion of UN is largely dependent on skin barrier integrity with a particular importance of stratum corneum. © The Author 2007. Published by Oxford University Press. All rights reserved. |
| Databáze: | OpenAIRE |
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