Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water
| Autor: | Chaithra Nagaraju, Yatheesh Narayana, Rangappa S. Kanchugarkoppal, Swarup Hassan Ashok, Sandhya C. Nagarakere, Mantelingu Kempegowda |
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| Rok vydání: | 2021 |
| Předmět: | |
| DOI: | 10.6084/m9.figshare.16784067 |
| Popis: | A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C���N and S���N bonds formation in a one-pot reaction under catalyst-free conditions. Operational simplicity, low cost, broad substrate scope and readily available starting materials are the main features of this protocol. |
| Databáze: | OpenAIRE |
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