Differences between Acute Exacerbations of Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases

Autor:	Sara Conti, Stefania Cerri, Ada Vancheri, Matteo Della Zoppa, Paola Faverio, Federica De Giacomi, Enrico Clini, Fabiana Madotto, Maria Rosaria Pellegrino, Fabrizio Luppi, Alberto Pesci, Lorenzo G. Mantovani, Anna Stainer, Roberto Tonelli
Přispěvatelé:	Faverio, P, Stainer, A, Conti, S, Madotto, F, De Giacomi, F, Zoppa, M, Vancheri, A, Pellegrino, M, Tonelli, R, Cerri, S, Clini, E, Mantovani, L, Pesci, A, Luppi, F
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Medicine (General) medicine.medical_specialty Exacerbation Lymphocytosis Clinical Biochemistry progressive fibrosing interstitial lung disease Gastroenterology Article fibrosing lung diseases Idiopathic pulmonary fibrosis R5-920 Internal medicine medicine acute exacerbation idiopathic pulmonary fibrosis Lung Idiopathic pulmonary fibrosi business.industry respiratory system medicine.disease Connective tissue disease Pulmonary hypertension Neutrophilia Fibrosing lung disease respiratory tract diseases medicine.anatomical_structure Cohort medicine.symptom business
Zdroj:	Diagnostics Diagnostics, Vol 11, Iss 1623, p 1623 (2021) Volume 11 Issue 9
ISSN:	2075-4418
Popis:	Interstitial lung diseases (ILDs) comprise a wide group of pulmonary parenchymal disorders. These patients may experience acute respiratory deteriorations of their respiratory condition, termed “acute exacerbation” (AE). The incidence of AE-ILD seems to be lower than idiopathic pulmonary fibrosis (IPF), but prognosis and prognostic factors are largely unrecognized. We retrospectively analyzed a cohort of 158 consecutive adult patients hospitalized for AE-ILD in two Italian university hospitals from 2009 to 2016. Patients included in the analysis were divided into two groups: non-IPF (62%) and IPF (38%). Among ILDs included in the non-IPF group, the most frequent diagnoses were non-specific interstitial pneumonia (NSIP) (42%) and connective tissue disease (CTD)-ILD (20%). Mortality during hospitalization was significantly different between the two groups: 19% in the non-IPF group and 43% in the IPF group. AEs of ILDs are difficult-to-predict events and are burdened by relevant mortality. Increased inflammatory markers, such as neutrophilia on the differential blood cell count (HR 1.02 (CI 1.01–1.04)), the presence of pulmonary hypertension (HR 1.85 (CI 1.17–2.92)), and the diagnosis of IPF (HR 2.31 (CI 1.55–3.46)), resulted in negative prognostic factors in our analysis. Otherwise, lymphocytosis on the differential count seemed to act as a protective prognostic factor (OR 0.938 (CI 0.884–0.995)). Further prospective, large-scale, real-world data are needed to support and confirm the impact of our findings.
Databáze:	OpenAIRE
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