Antiproliferative Effect and Cell Cycle Alterations Induced by Salvia officinalis Essential Oil and Its Three Main Components in Human Colon Cancer Cell Lines
| Autor: | Edoardo Napoli, Tonia Luca, Giovanna Privitera, Sergio Castorina, Nicolò Musso, Giuseppe Ruberto |
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| Rok vydání: | 2020 |
| Předmět: |
Cell cycle checkpoint
Colorectal cancer In vitro cell culture Bioengineering colorectal cancer in vitrocell culture 01 natural sciences Biochemistry essential oil law.invention chemistry.chemical_compound food law Cell Line Tumor medicine Oils Volatile Humans MTT assay Salvia officinalis Molecular Biology essential oils Essential oil Cell Proliferation 010405 organic chemistry Chemistry Cell growth Cell Cycle General Chemistry General Medicine Cell cycle medicine.disease Flow Cytometry food.food 0104 chemical sciences 010404 medicinal & biomolecular chemistry Eucalyptol Colonic Neoplasms Cancer research Molecular Medicine cell cycle checkpoint |
| Zdroj: | Chemistry & biodiversity 17 (2020). doi:10.1002/cbdv.202000309 info:cnr-pdr/source/autori:Luca, Tonia; Napoli, Edoardo; Privitera, Giovanna; Musso, Nicolo; Ruberto, Giuseppe; Castorina, Sergio/titolo:Antiproliferative Effect and Cell Cycle Alterations Induced bySalvia officinalisEssential Oil and Its Three Main Components in Human Colon Cancer Cell Lines/doi:10.1002%2Fcbdv.202000309/rivista:Chemistry & biodiversity (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:17 |
| ISSN: | 1612-1880 |
| DOI: | 10.1002/cbdv.202000309 |
| Popis: | Colon cancer is one of the most common human malignancies, and chemotherapy cannot yet prevent recurrence in all patients. Essential oils are phytocomplexes with antiproliferative properties. In this study, we elucidated the antiproliferative properties and the effect on cell cycle progression of Sicilian Salvia officinalis essential oil and its three main compounds, α-thujone, 1,8-cineole (eucalyptol) and camphor, on three human colon cancer cell lines. The essential oil was obtained by hydrodistillation and analyzed by gas chromatography. Cell proliferation was evaluated by MTT assay, and the cell cycle distribution was determined by flow cytometry. Thirty-four compounds were identified in the tested essential oil. Growth inhibition was observed after 72 h, with an impact on cell cycle progression and no effect on the viability of normal colonic epithelial cells. The study shows that S. officinalis essential oil and its three main components have an in vitro antiproliferative effect on colon cancer cells. |
| Databáze: | OpenAIRE |
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