HIV-infected progressors and long-term non-progressors differ in their capacity to respond to an A-class CpG oligodeoxynucleotide
| Autor: | Emilio Cuadrado, Maria Dolores de Juan, José Antonio Iribarren, Raquel Saez, Pilar Echaniz |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
CpG Oligodeoxynucleotide
Immunology HIV Infections Asymptomatic Interferon-gamma Acquired immunodeficiency syndrome (AIDS) Immunopathology Hiv infected medicine Humans Immunology and Allergy Sida Innate immune system biology biology.organism_classification medicine.disease Virology Killer Cells Natural Infectious Diseases Oligodeoxyribonucleotides Case-Control Studies Disease Progression Viral disease medicine.symptom Follow-Up Studies |
| Zdroj: | AIDS. 19:1924-1925 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/01.aids.0000191229.52385.5f |
| Popis: | We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts. |
| Databáze: | OpenAIRE |
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