Clinical characteristics of interim-PET negative patients with a positive end PET from the prospective HD08-01 FIL study
| Autor: | Alessandro Pulsoni, Barbara Botto, Alessandro Re, Manuel Gotti, Michele Spina, Luigi Rigacci, Andrea Evangelista, Sofia Kovalchuk, Daniela Gioia, Lara Mannelli, Manjola Dona, Luca Nassi, Benedetta Puccini, Alessandro Broccoli, Caterina Stelitano, Flavia Salvi, Armando Santoro, Chiara Pagani, Pier Luigi Zinzani, Maurizio Bonfichi |
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| Přispěvatelé: | Rigacci, Luigi, Puccini, Benedetta, Broccoli, Alessandro, Dona, Manjola, Gotti, Manuel, Evangelista, Andrea, Santoro, Armando, Bonfichi, Maurizio, Re, Alessandro, Spina, Michele, Botto, Barbara, Pulsoni, Alessandro, Pagani, Chiara, Stelitano, Caterina, Salvi, Flavia, Nassi, Luca, Mannelli, Lara, Kovalchuk, Sofia, Gioia, Daniela, Zinzani, Pier Luigi |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Salvage therapy Vinblastine Procarbazine Gastroenterology Disease-Free Survival advanced Hodgkin lymphoma interim-PET prognosis Bleomycin 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Internal medicine Antineoplastic Combined Chemotherapy Protocols Biopsy medicine Humans Prospective Studies Autografts Prospective cohort study Survival rate medicine.diagnostic_test business.industry Standard treatment Retrospective cohort study Hematology General Medicine Hodgkin Disease Dacarbazine Survival Rate Doxorubicin Positron-Emission Tomography 030220 oncology & carcinogenesis Prednisolone Female business Stem Cell Transplantation 030215 immunology medicine.drug |
| Popis: | FDG-positron emission tomography (PET) performed early during therapy in advanced Hodgkin lymphoma patients has been confirmed as being important for progression-free survival. A group of patients with a negative interim-PET (i-PET) showed a positive end induction PET (e-PET). The aim of this study was to evaluate the clinical characteristics of patients with a positive e-PET as a secondary end point of the HD0801 study. A total of 519 patients with advanced-stage de novo Hodgkin lymphoma received initial treatment and underwent an i-PET. Patients with negative results continued the standard treatment. i-PET negative patients were then evaluated for response with an e-PET and those patients found to have a positive one were also then given a salvage therapy. Among 409 i-PET negative, 16 interrupted the therapy, 393 patients were evaluated with an e-PET, and 39 were positive. Sixteen out of 39 underwent a diagnostic biopsy and 15 were confirmed as HD. Seventeen out of 39 e-PET were reviewed according to the Deauville Score and, in sixteen, it was confirmed positive (10 DS 5, 6 DS 4). With the exception of high LDH value at diagnosis (p = 0.01; HR 95% CI 1.18-4.89), no clinical characteristics were significantly different in comparison with e-PET negative patients. Positive e-PET after a negative i-PET has a worse outcome when compared with i-PET positive patients salvaged with therapy intensification. It was not possible to identify clinical characteristics associated with a positive e-PET. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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