Regulation of sympathetic presynaptic components in rat left ventricle during ligation of abdominal aorta
| Autor: | J. M. Hitchcock, C. Unal, V. R. Evans, C. Nyquist-Battie, P. K. Cochran |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Sympathetic nervous system medicine.medical_specialty Sympathetic Nervous System Time Factors Physiology Presynaptic Terminals Methyltyrosines Ventricular Function Left Rats Sprague-Dawley Norepinephrine Fluoxetine Physiology (medical) Internal medicine medicine Animals Neuropeptide Y Aorta Abdominal Ligation Pressure overload Binding Sites Norepinephrine Plasma Membrane Transport Proteins Symporters Tyrosine hydroxylase business.industry Myocardium Nisoxetine Neuropeptide Y receptor Rats medicine.anatomical_structure Endocrinology Ventricle Hypertension Circulatory system cardiovascular system Carrier Proteins Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 271:H1547-H1554 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1996.271.4.h1547 |
| Popis: | To assess the effects of long-term pressure overload on sympathetic presynaptic components in the left ventricle, young adult male rats were subjected to surgical constriction of the suprarenal abdominal aorta. At 4 and 8 wk postsurgery, but not at 1 wk, left ventricular sympathetic activity, measured by the net fractional norepinephrine (NE) decrease after alpha-methyl-p-tyrosine methyl ester administration, was elevated in the aortic-banded rats. However, left ventricular NE was reduced only at 8 wk. Scatchard analysis of saturation binding of [3H]nisoxetine, a specific ligand for NE uptake sites, determined that left ventricular NE transporter sites were also reduced at 8 wk, suggesting a relationship between a reduced number of uptake sites and loss of NE stores. In contrast, aortic constriction did not reduce neuropeptide Y (NPY), tyrosine hydroxylase, dopamine beta-hydroxylase, nervegrowth factor, and low-affinity nerve growth factor receptors at any time point. Thus long-term pressure overload can cause a selective reduction in ventricular NE stores without a reduction in NPY, a colocalized sympathetic neurotransmitter. |
| Databáze: | OpenAIRE |
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