Human Liver Neoplasia and Steroid Exposure
| Autor: | E. Truman Mays, George H. Barrows, William M. Christopherson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Liver tumor Human liver 040301 veterinary sciences business.industry Research methodology medicine.medical_treatment Focal nodular hyperplasia Histology 04 agricultural and veterinary sciences Cell Biology medicine.disease Toxicology 030226 pharmacology & pharmacy Steroid Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences Health services 0302 clinical medicine Medicine business Molecular Biology |
| Zdroj: | Toxicologic pathology. 10(2) |
| ISSN: | 1533-1601 |
| Popis: | This study examines experience with over 250 liver tumors in young women. Most were oral contraceptive related. There were two distinct benign liver tumor types: focal nodular hyperplasia and liver cell adenoma. Six benign liver tumors were examined for estrogen receptors. They did not contain significant quantities of estrogen receptor, supporting experimental studies of an epigenetic origin. Multiple tumors occurred in about 20% of cases but did not change the favorable prognosis associated with benign tumors. The most significant source of morbidity and mortality was spontaneous hemorrhage or rupture. Twenty-three women in this series had hepatocellular carcinoma and the majority of these were associated with prolonged steroid usage. These malignant liver tumors occurred in young females without cirrhosis or other factors known to be associated with hepatic malignancy. Unlike “hepatocellular carcinomas” reported in males taking anabolic androgenic steroids, the tumors in females had a high rate of metastasis to a variety of organs. The risk of liver tumors in oral contraceptive users remains unknown, but must be very small since an estimated 150 million women worldwide and 40 million in the U.S.A. have used oral contraceptives. |
| Databáze: | OpenAIRE |
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