Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats
| Autor: | Sheema H Hasan, Tasneem Fatima, Shahid Pervez, Darakhshan Jabeen Haleem, Tafheem Malik |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Dyskinesia Drug-Induced Movement disorders Side effect Striatum Motor Activity Pharmacology 030226 pharmacology & pharmacy Biochemistry Nucleus Accumbens 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Basal Ganglia Diseases Extrapyramidal symptoms Haloperidol Animals Plant Oils Tardive Dyskinesia Medicine Gliosis Nigella sativa Rats Wistar biology business.industry Parkinsonism General Medicine medicine.disease biology.organism_classification Nigella Dyskinesia Astrocytes Anesthesia Caudate Nucleus medicine.symptom business 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug |
| Zdroj: | Neurochemical Research. 41:3386-3398 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-016-2073-z |
| Popis: | The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect. |
| Databáze: | OpenAIRE |
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