Unusual T- and T/NK- cell non-Hodgkin's lymphoma of the larynx: a diagnostic challenge for clinicians and pathologists
| Autor: | John Chow, Johnny S. W. Mok, Martin Wai Pak, Charles Andrew van Hasselt, K F Chan |
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| Rok vydání: | 2001 |
| Předmět: |
Larynx
Adult Male medicine.medical_specialty Pathology medicine.medical_treatment T cell Disease Lymphoma T-Cell Fatal Outcome hemic and lymphatic diseases medicine Humans Medical diagnosis Laryngeal Neoplasms Retrospective Studies business.industry Lymphoma T-Cell Peripheral Laryngeal Neoplasm Middle Aged medicine.disease Prognosis Dermatology Non-Hodgkin's lymphoma Lymphoma Radiation therapy Killer Cells Natural medicine.anatomical_structure Otorhinolaryngology business |
| Zdroj: | Headneck. 23(8) |
| ISSN: | 1043-3074 |
| Popis: | Background Lymphomas of T-cell and T/natural killer (T/NK)-cell types rarely involve the larynx. Early symptoms are subtle and nonspecific, and confirmation of the diagnosis is often difficult. Because of the rarity of this disease entity, the optimal management remains controversial. Methods The case records of patients with the diagnosis of lymphoma involving the larynx were retrospectively reviewed. Details of the pathologic condition, the difficulties in diagnosis, and treatment were presented. Results One case of T-cell lymphoma (Lennert's lymphoma subtype) and two cases of T/NK-cell lymphomas involving the larynx were presented. The diagnoses were all difficult to establish. All three patients received either multiagent chemotherapy or radiotherapy as the first-line treatment. They all died of the disease within 32 months of diagnosis. Conclusions T- and T/NK-cell non-Hodgkin's lymphoma of the larynx is a diagnostic challenge for clinicians and pathologists. Conventional chemotherapy or radiotherapy has not been effective. A more aggressive therapy should be considered. © 2001 John Wiley & Sons, Inc. Head Neck 23: 625–628, 2001. |
| Databáze: | OpenAIRE |
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