Computer-aided biokinetic modelling combined with in vitro data

Autor:	J.J.M. van de Sandt, Bas J. Blaauboer, J. De Jongh, Erna M. Hissink, P.J. van Bladeren, J.J.P. Bogaards, B. van Ommen
Přispěvatelé:	Instituut CIVO-Toxicologie en Voeding TNO
Rok vydání:	1995
Předmět:	Toxicology In vivo Computer aid Sus scrofa Computer-aided Animalia General Medicine Biochemical engineering Biology Oryctolagus cuniculus In vitro
Zdroj:	Toxicology in Vitro, 4, 9, 537-542
ISSN:	0887-2333
Popis:	Within the framework of in vitro alternatives for in vivo safety assessment, the kinetic behaviour of a compound can be described by biokinetic models. These models, with emphasis on the physiologically based pharmacokinetic models, need a variety of biological, physicochemical and biochemical parameters. This paper deals with the possibilities for obtaining these data from in vitro studies. Examples are given for parameters on absorption (both dermal and intestinal), distribution and metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c7060b81e8395aea8573aa04bd8def https://doi.org/10.1016/0887-2333(95)00046-b Zobrazit plný text záznamu Full Text from ScienceDirect