PPARα and γ Activation Effects of New Nor-triterpenoidal Saponins from the Aerial Parts of Anabasis articulata
| Autor: | Riham Salah El Dine, Shabana I. Khan, Hossam M. Abdallah, Ahmed A. Zaki, Ikhlas A. Khan, Zeinab A. Kandil |
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| Rok vydání: | 2018 |
| Předmět: |
Magnetic Resonance Spectroscopy
ved/biology.organism_classification_rank.species Saponin Pharmaceutical Science Pharmacology 01 natural sciences Analytical Chemistry boats Triterpenoid boats.ship_class Drug Discovery Articulata Humans Hypoglycemic Agents PPAR alpha Receptor Medicinal plants chemistry.chemical_classification Amaranthaceae Plant Extracts Terpenes 010405 organic chemistry ved/biology Organic Chemistry Anabasis articulata Hep G2 Cells Saponins Peroxisome 0104 chemical sciences PPAR gamma carbohydrates (lipids) 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Nuclear receptor Molecular Medicine |
| Zdroj: | Planta Medica. 85:274-281 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Anabasis articulata, traditionally used to treat diabetes, is rich in saponin content. This study was performed to investigate the agonistic effect of its saponins on peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-γ in human hepatoma (HepG2) cells to explore the possibility of the involvement of these nuclear receptors in the mechanism of the antidiabetic effect of the plant. Chemical investigation of the n-butanol fraction resulted in the isolation of three new and one known 30-noroleanane triterpenoid saponins. The structures of the new compounds were elucidated as 3β-hydroxy,23-aldehyde-30-norolean-12,20(29)-dien-28-oic acid-28-O-β-D-glucopyranosyl ester (1), 3β-O-D-galactopyranosyl-23-aldehyde-30-norolean-12,20(29)-dien-28-oic acid-28-O-β-D-glucopyranosyl ester (2), and 3β-O-D-xylopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-β-D-glucopyranosyl ester (3), while the known 30-nortriterpenoidal saponin was identified as boussingoside E (4). Although, the isolated saponins (1 – 4) did not show > 1.5-fold activation of peroxisome proliferator-activated receptor-γ, but two of them (1 and 3) activated peroxisome proliferator-activated receptor-α to the higher extents of 2.25- and 1.86-fold, respectively. These results suggest that the reported antidiabetic action of the isolated saponins may not solely involve the activation of peroxisome proliferator-activated receptor-γ. However, the agonistic activity of the n-butanol fraction of A. articulata (1.71-fold induction) and two of its saponins (1 and 3) towards peroxisome proliferator-activated receptor-α may be beneficial in the cardiovascular condition that is closely associated with diabetes and other metabolic disorders. |
| Databáze: | OpenAIRE |
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