Hemodynamic effect of dobutamine in patients with severe heart failure
| Autor: | M.Hafeez Chaudhry, Esteban Mikulic, Nasim Akhtar, Jay N. Cohn |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Chronotropic
Adult medicine.medical_specialty Mean arterial pressure Cardiac output Cardiac Catheterization Dopamine Hemodynamics Blood Pressure Oxygen Consumption Heart Conduction System Internal medicine Heart rate medicine Animals Humans Cardiac Output Pulmonary wedge pressure Heart Failure business.industry Myocardium Middle Aged medicine.disease Myocardial Contraction Anesthesia Heart failure Cardiology Dobutamine Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American journal of cardiology. 36(2) |
| ISSN: | 0002-9149 |
| Popis: | Dobutamine, a derivative of dopamine, was infused at a rate of 10 mug/kg per min in 15 patients with severe congestive heart failure. Cardiac output increased from an average of 3.1 to 5.6 liters/min (P less than 0.001) with no change in mean arterial pressure (93.3 to 98.2 mm Hg) and only a slight increase in heart rate (98.5 to 105.2 beats/min) (P less than 0.02). Pulmonary wedge pressure was decreased from an average of 27.4 to 21.1 mm Hg (P less than 0.001). In seven patients a dose of 5 mug/kg per min also produced a significant increase in cardiac output but the effect was less than with the 10 mug/kg per min dose. No side effects were observed during the infusion. Dobutamine therefore is a potent inotropic drug with limited chronotropic and peripheral vascular effects and deserves therapeutic trial in the short-term management of low output heart failure. |
| Databáze: | OpenAIRE |
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