The Common and Distinct Features of Brown and Beige Adipocytes
| Autor: | Shingo Kajimura, Pema Maretich, Kenji Ikeda |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Adipose tissue Thermogenesis Mitochondrion Biology Beige Adipocytes Thermogenin Energy homeostasis Article Cell biology Mitochondrial Proteins 03 medical and health sciences 030104 developmental biology Endocrinology Adipocytes Brown Lipid droplet Glucose homeostasis Animals Homeostasis Humans Adipocytes Beige Energy Metabolism Function (biology) Uncoupling Protein 1 |
| Zdroj: | Trends in endocrinology and metabolism: TEM. 29(3) |
| ISSN: | 1879-3061 |
| Popis: | Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat possess thermogenic properties in addition to common morphological and biochemical characteristics, including multilocular lipid droplets and cristae-dense mitochondria. Recent studies also identify features that are distinct between the two types of thermogenic fat cells, such as their developmental regulation and function. Of particular interest is the role of beige fat in the regulation of glucose homeostasis via uncoupling protein 1 (UCP1)-independent mechanisms. A better understanding of the underlying causes of these characteristics of brown and beige fat will allow us to specifically manipulate these cells to improve systemic energy metabolism and glucose homeostasis. |
| Databáze: | OpenAIRE |
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