Vagally mediated sympathoexcitation and central depression by desflurane in rabbits
| Autor: | Daqing Ma, J. G. Whitwam, Chen Pac-Soo, M. K. Chakrabarti, C. Wang |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Sympathetic nervous system Sympathetic Nervous System medicine.medical_treatment Blood Pressure Vagotomy Kidney Desflurane Heart Rate medicine Animals Depression (differential diagnoses) Isoflurane business.industry Sympathetic nerve activity Vagus Nerve Sympathetic activity Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Anesthetics Inhalation Female Rabbits business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 84:777-782 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/oxfordjournals.bja.a013593 |
| Popis: | The effects of desflurane on renal sympathetic nerve activity (RSNA) were studied in intact or vagotomized anaesthetized rabbits with initial concentrations of 4.5-18%, subsequently equilibrated to end-tidal concentrations from 3%, 6%, 9% and 12% each for 20 min allowing sympathetic activity to stabilize. In intact animals, immediate transient increases in mean sympathetic activity from 27% to 63% were closely related to initial concentrations from 4.5% to 18%. During subsequent equilibration this remained elevated by 25-30% up to 6%, returned to control at 9% and fell by 33% at 12%. Bilateral vagotomy abolished sympathoexcitation apart from small increases in sympathetic activity, for example 14% at 4.5% (P0.05). We conclude that increases in inspired desflurane concentrations evoked rapid transient vagally mediated reflex sympathoexcitation with a small extra-vagal contribution. Central depression of sympathetic activity started at 6% and was 33% below baseline at 12%. |
| Databáze: | OpenAIRE |
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