Systemic effects after intravitreal injection of bevacizumab in new born rabbit eyes
| Autor: | Yin-Cheng Huang, Yen-Po Chen, Wei-Chi Wu, Kwan-Jen Chen, Tun-Lu Chen, Chih-Shan Chen, Nan-Kai Wang, Yih-Shiou Hwang, Chi-Hsien Liu, Chi-Chun Lai |
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| Rok vydání: | 2017 |
| Předmět: |
Bevacizumab
Balanced salt solution Angiogenesis Inhibitors Toxicology Eye 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Ocular Physiological Phenomena medicine.diagnostic_test business.industry Complete blood count Retinopathy of prematurity Histology General Medicine medicine.disease Vascular endothelial growth factor Blood pressure chemistry Animals Newborn 030220 oncology & carcinogenesis Anesthesia Intravitreal Injections 030221 ophthalmology & optometry Rabbits medicine.symptom business Weight gain medicine.drug |
| Zdroj: | Cutaneous and ocular toxicology. 37(1) |
| ISSN: | 1556-9535 |
| Popis: | To determine the systemic impact of intravitreal injection of bevacizumab (IVB), an anti-vascular endothelium growth factor antibody, in newborn rabbits.We used four groups of rabbits. Group 1 rabbits received a single injection of IVB starting from the age of 6 weeks. Group 2 rabbits received a single injection of balanced salt solution (BSS, 0.025 ml) and served as controls for group 1. Group 3 rabbits received two consecutive injections of IVB at the ages of 6 and 10 weeks. Group 4 rabbits received two consecutive injections of BSS at the ages of 6 and 10 weeks and served as controls for group 3. During the experiment, a complete blood count (CBC), clinical biochemistry, weight gain, food intake, body temperature, blood pressure, pulse, and mortality were measured in the animals. Two months after IVB injection, the animals were sacrificed, and histology of the major organs was checked. Immunohistochemistry was assessed to explore the neurons in the central nervous system (CNS).We found there were no morphological or functional changes in the eyes following IVB injection. Furthermore, there were no differences in CBC, biochemistry, or other measured parameters among the four groups of animals. We checked the histology of the major organs and neurons in the CNS and they did not reveal significant differences among the four groups of animals.Conclusively, IVB of either one or two injections (0.625 mg) in newborn rabbit eyes is well tolerated and does not cause noticeable systemic organ pathology. |
| Databáze: | OpenAIRE |
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