A comparison of multi-objective optimization algorithms to identify drug target combinations
| Autor: | Spolaor, Simone, Papetti, Daniele M., Cazzaniga, Paolo, Besozzi, Daniela, Nobile, Marco S., Hallinan, Jennifer, Chetty, Madhu, Heredia, Gonzalo Ruz, Shatte, Adrian, Lim, Suryani |
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| Přispěvatelé: | Hallinan, J, Chetty, M, Heredia, GR, Shatte, A, Lim, S, Spolaor, S, Papetti, D, Cazzaniga, P, Besozzi, D, Nobile, M, Information Systems IE&IS |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Optimization problem
Mathematical model Settore INF/01 - Informatica Computer science Therapeutic target media_common.quotation_subject Fuzzy modeling Drug target Pareto principle fuzzy modeling multi-objective optimization global optimization cancer therapeutic targets combination chemotherapy SDG 3 – Goede gezondheid en welzijn Fuzzy logic Multi-objective optimization Combination chemotherapy Identification (information) SDG 3 - Good Health and Well-being Therapeutic targets Quality (business) Global optimization Algorithm media_common Cancer |
| Zdroj: | 2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) CIBCB |
| Popis: | Combination therapies represent one of the most effective strategy in inducing cancer cell death and reducing the risk to develop drug resistance. The identification of putative novel drug combinations, which typically requires the execution of expensive and time consuming lab experiments, can be supported by the synergistic use of mathematical models and multi-objective optimization algorithms. The computational approach allows to automatically search for potential therapeutic combinations and to test their effectiveness in silico, thus reducing the costs of time and money, and driving the experiments toward the most promising therapies. In this work, we couple dynamic fuzzy modeling of cancer cells with different multi-objective optimization algorithm, and we compare their performance in identifying drug target combinations. Specifically, we perform batches of optimizations with 3 and 4 objective functions defined to achieve a desired behavior of the system (e.g., maximize apoptosis while minimizing necrosis and survival), and we compare the quality of the solutions included in the Pareto fronts. Our results show that both the choice of the multi-objective algorithm and the formulation of the optimization problem have an impact on the identified solutions, highlighting the strengths as well as the limitations of this approach. |
| Databáze: | OpenAIRE |
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