Asymmetric Hydrogenation of Isoquinolinium Salts Catalyzed by Chiral Iridium Complexes: Direct Synthesis for Optically Active 1,2,3,4-Tetrahydroisoquinolines
| Autor: | Atsuhiro Iimuro, Takuto Nagano, Sathaiah Kandula, Kazushi Mashima, Kenta Yamaji, Yusuke Kita |
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| Rok vydání: | 2013 |
| Předmět: |
Asymmetric hydrogenation
Enantioselective synthesis chemistry.chemical_element Stereoisomerism General Medicine General Chemistry Optically active Iridium Catalysis chemistry.chemical_compound chemistry Coordination Complexes Tetrahydroisoquinolines Polymer chemistry Organic chemistry Hydrogenation Isoquinoline Enantiomeric excess |
| Zdroj: | Angewandte Chemie International Edition. 52:2046-2050 |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.201207748 |
| Popis: | In the presence of a chiral iridium catalyst, 1- and 3-substituted as well as 1,3-disubstituted isoquinolinium salts can be hydrogenated, giving the corresponding 1,2,3,4-tetrahydroisoquinolines in high enantiomeric excess. |
| Databáze: | OpenAIRE |
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