TNFα-stimulation of cFos-activation of neurons in the solitary nucleus is suppressed by TNFR:Fc adsorbant construct in the dorsal vagal complex
| Autor: | C. Amy Tovar, Richard C. Rogers, Gerlinda E. Hermann |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Microinjections Recombinant Fusion Proteins medicine.medical_treatment Central nervous system Alpha (ethology) Stimulation Biology Receptors Tumor Necrosis Factor Etanercept Internal medicine Solitary Nucleus medicine Animals Rats Long-Evans Molecular Biology Injections Intraventricular Neurons Medulla Oblongata Tumor Necrosis Factor-alpha General Neuroscience Solitary nucleus Vagus Nerve Rats Vagus nerve Autonomic nervous system Endocrinology Cytokine medicine.anatomical_structure Immunoglobulin G Tumor necrosis factor alpha Neurology (clinical) Proto-Oncogene Proteins c-fos Developmental Biology |
| Zdroj: | Brain Research. 976:69-74 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(03)02687-8 |
| Popis: | The cytokine tumor necrosis factor alpha (TNF(alpha)) may act within the neural circuitry of the medullary dorsal vagal complex (DVC) to affect changes in gastric function such as gastric stasis, loss of appetite, nausea, and vomiting. The definitive demonstration that endogenously generated TNF(alpha) is acting within the DVC circuitry to affect these changes has been impeded by the lack of an antagonist for TNF(alpha). The present studies used localized central nervous system microinjections of the TNF-adsorbant construct (TNFR:Fc) to specifically neutralize the ability of endogenously produced TNF(alpha) to activate NST neurons. Our studies reveal that TNFR:Fc suppresses induction of cFos normally evoked by TNF(alpha). These results validate our hypothesis that circulating TNF(alpha) may act directly within the DVC to affect gastric function in a variety of pathophysiological states. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect