Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms
| Autor: | Paul T. Francis, G. C. Stratmann, David M. Bowen, Andrew W. Procter |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Serotonin
medicine.medical_specialty Pathology Neurology Serotonergic Biochemistry Choline O-Acetyltransferase Radioligand Assay Cellular and Molecular Neuroscience Degenerative disease Neurochemical Alzheimer Disease Interneurons medicine Humans Neurochemistry gamma-Aminobutyric Acid Aged Retrospective Studies Aged 80 and over Cerebral Cortex General Medicine Middle Aged medicine.disease Aggression medicine.anatomical_structure Cerebral cortex Alzheimer's disease Peptides Somatostatin Psychology Biomarkers |
| Zdroj: | Neurochemical Research. 17:917-922 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/bf00993268 |
| Popis: | Behavioural symptoms of Alzheimer's disease, such as aggression, may determine the care patients required. Most postmortem neurochemical studies have been of institutionalized patients and conclusions drawn from these may not be valid for all patients. We have shown that serotonin 2 receptors are not lost from 12 of the 13 areas of cerebral cortex examined in the patients assessed to be free of aggressive symptoms. This has been interpreted as representing the relative preservation of cortical interneurones. In contrast choline acetyltransferase activity was reduced in all areas whereas serotonin content was reduced in only 2 of the 4 areas examined. |
| Databáze: | OpenAIRE |
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