Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers
Autor: | Sybille Buchwald-Werner, Claudia Reule, Sonja Frank, Christiane Schön |
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Rok vydání: | 2017 |
Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Pharmaceutical Science 030209 endocrinology & metabolism Carbohydrate metabolism Placebo Analytical Chemistry Microcirculation law.invention 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Internal medicine Drug Discovery Humans Medicine Mangifera Reactive hyperemia Aged Pharmacology business.industry Organic Chemistry Middle Aged 030104 developmental biology Postprandial Endocrinology Complementary and alternative medicine Molecular Medicine Female Plant Preparations business Phytotherapy |
Zdroj: | Planta Medica. 83:824-829 |
ISSN: | 1439-0221 0032-0943 |
Popis: | A commercial Mangifera indica fruit powder (Careless) showed beneficial acute effects on microcirculation in a randomized, double-blind, crossover pilot study. Here, long-term effects on microcirculation and glucose metabolism were investigated in a double-blind, randomized, placebo-controlled, 3-arm parallel-design study in healthy individuals. A daily dose of 100 mg or 300 mg of the fruit powder was compared to placebo after supplementation for 4 weeks. Microcirculation and endothelial function were assessed by the Oxygen-to-see System and pulse amplitude tonometry, respectively. Glucose metabolism was assessed under fasting and postprandial conditions by capillary glucose and HbA1c values.Microcirculatory reactive hyperemia flow increased, especially in the 100 mg group (p = 0.025). The 300 mg of the M. indica fruit preparation reduced postprandial glucose levels by trend if compared to placebo (p = 0.0535) accompanied by significantly lower HbA1c values compared to baseline. Furthermore, 300 mg intake significantly improved postprandial endothelial function in individuals with decreased endothelial function after high-dose glucose intake (p = 0.0408; n = 11).In conclusion, the study suggests moderate beneficial effects of M. indica fruit preparation on microcirculation, endothelial function, and glucose metabolism. |
Databáze: | OpenAIRE |
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