Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs
| Autor: | María Jimena Messina, Matías Daniel Caverzán, C Errecalde, Natalia Urzúa, Carlos Lüders, Guillermo F. Prieto |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Sucralfate Health Toxicology and Mutagenesis Administration Oral Biological Availability Levofloxacin Pharmacology Toxicology 030226 pharmacology & pharmacy Biochemistry 03 medical and health sciences Dogs 0302 clinical medicine Anti-Infective Agents Pharmacokinetics Oral administration medicine Animals Drug Interactions Bacteria business.industry General Medicine Breed Anti-Bacterial Agents stomatognathic diseases Area Under Curve 030220 oncology & carcinogenesis Administration Intravenous business medicine.drug |
| Zdroj: | Xenobiotica. 50:1490-1493 |
| ISSN: | 1366-5928 0049-8254 |
| Popis: | The study aims to establish the plasma pharmacokinetic parameters of levofloxacin in mixed-breed dogs, at a single dose of 5 mg/kg, intravenously, orally only and orally with sucralfate pre-treatment (1 g per animal), to evaluate its influence on antimicrobial absorption. Concentrations of levofloxacin in plasma were determined using high-performance liquid chromatography (HPLC) with fluorescence detection. After iv of levofloxacin, the mean (±SD) of AUC |
| Databáze: | OpenAIRE |
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