Expression of NM23 Protein in Acquired Melanocytic Nevi, Malignant Melanoma and Metastases of Malignant Melanoma: An Immunohistological Assessment in Human Skin
| Autor: | Jörg Reichrath, F.A. Bahmer, R. Braun, P. Seyfried, H.-P. Baum, S. M. Müller |
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| Rok vydání: | 1997 |
| Předmět: |
Cytoplasm
Pathology medicine.medical_specialty Skin Neoplasms Tumor suppressor gene Human skin Dermatology Biology Metastasis Immunoenzyme Techniques Antigens Neoplasm Biomarkers Tumor medicine Humans Genes Tumor Suppressor Metastasis suppressor Melanoma Monomeric GTP-Binding Proteins Cell Nucleus Nevus Pigmented Paraffin Embedding Intracellular Membranes NM23 Nucleoside Diphosphate Kinases Melanocytic nevus medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic Phenotype Nucleoside-Diphosphate Kinase Melanocytes Dysplastic Nevus Syndrome Transcription Factors |
| Zdroj: | Dermatology. 194:136-139 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000246082 |
| Popis: | It has been suggested that nm23 may exert metastasis suppressor function in human tumors.We have analyzed expression of nm23 polypeptide in acquired melanocytic nevi (n = 19), dysplastic nevi (n = 19), malignant melanomas (n = 22) and metastases of malignant melanomas (n = 47) in situ.Nm23 protein was detected immunohistochemically on paraffin sections using the highly sensitive labeled avidin-biotin technique.We found that (1) nm23 polypeptide is predominantly expressed in the cytoplasmic but also in nuclear and membrane compartments of melanocytic human cells, (2) expression of nm23 protein does not correlate with benign or malignant phenotype in melanocytic tumors of human skin.Our study challenges the hypothesis that nm23 may function in malignant melanomas as a tumor suppressor gene. |
| Databáze: | OpenAIRE |
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