Specificity and plasticity of thalamocortical connections in Sema6A mutant mice
| Autor: | Maria Carmen Piñon, Alain Chédotal, Guillermina López-Bendito, Graham E. Little, Annette E. Rünker, Zoltán Molnár, Noelia García, Kevin J. Mitchell |
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| Přispěvatelé: | Autard, Delphine, Smurfit Institute of Genetics, Trinity College Dublin, Instituto de Neurociencias de Alicante, Universidad Miguel Hernández [Elche] (UMH)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Department of Physiology, Anatomy and Genetics, University of Oxford, Institut de la Vision, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from Science Foundation Ireland (01/F1/B006) to KJM, Spanish Ministry of Science and Innovation (grants BFU2006-00408 and CONSOLIDER-INGENIO 2010 CSD2007-00023) to GLB, and a Medical Research Council (MRC) Career Establishment Award (G0300200) and Project Grant (G0700377) to ZM. AC is supported by the Fondation pour la Recherche Medicale (programme équipe FRM). GL has been supported by a Government of Ireland Scholarship, awarded by the Irish Research Council of Science, Engineering and Technology. AR was supported by a Health Research Board Postdoctoral Fellowship., University of Oxford [Oxford], Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Telencephalon
MESH: Semaphorins Semaphorins MESH: Mice Knockout Mice 0302 clinical medicine Thalamus Cortex (anatomy) MESH: Animals MESH: Neuronal Plasticity Biology (General) Visual Cortex MESH: Thalamus Mice Knockout 0303 health sciences Neuronal Plasticity Neocortex Cerebrum General Neuroscience Geniculate Bodies Anatomy 3. Good health medicine.anatomical_structure Thalamic Nuclei Recurrent thalamo-cortical resonance [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female General Agricultural and Biological Sciences Research Article MESH: Axons QH301-705.5 Sensory system Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences MESH: Thalamic Nuclei medicine Animals Visual Pathways [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Mice MESH: Geniculate Bodies 030304 developmental biology MESH: Visual Pathways General Immunology and Microbiology MESH: Visual Cortex Axons Visual cortex MESH: Telencephalon Axon guidance MESH: Female Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | PLoS Biology PLoS Biology, Vol 7, Iss 4, p e98 (2009) PLoS Biology, 2009, 7 (4), pp.e98. ⟨10.1371/journal.pbio.1000098⟩ PLoS Biology, Public Library of Science, 2009, 7 (4), pp.e98. ⟨10.1371/journal.pbio.1000098⟩ Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1544-9173 1545-7885 |
| Popis: | 15 pages, 9 figures.-- Supporting information (Suppl. figs S1-S3) available at: http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.1000098#toclink6 The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model to test current ideas on the interactions between subcortical and cortical guidance mechanisms and cortical regionalization. In these mutants, axons from the dorsal lateral geniculate nucleus (dLGN) are misrouted in the ventral telencephalon. This leads to invasion of presumptive visual cortex by somatosensory thalamic axons at embryonic stages. Remarkably, the misrouted dLGN axons are able to find their way to the visual cortex via alternate routes at postnatal stages and reestablish a normal pattern of thalamocortical connectivity. These findings emphasize the importance and specificity of cortical cues in establishing thalamocortical connectivity and the spectacular capacity of the early postnatal cortex for remapping initial sensory representations. This work was supported by grants from Science Foundation Ireland (01/F1/B006) to KJM, Spanish Ministry of Science and Innovation (grants BFU2006–00408 and CONSOLIDER-INGENIO 2010 CSD2007–00023) to GLB, and a Medical Research Council (MRC) Career Establishment Award (G0300200) and Project Grant (G0700377) to ZM. AC is supported by the Fondation pour la Recherche Medicale (programme équipe FRM). GL has been supported by a Government of Ireland Scholarship, awarded by the Irish Research Council of Science, Engineering and Technology. AR was supported by a Health Research Board Postdoctoral Fellowship. |
| Databáze: | OpenAIRE |
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