Potentiation of Isoniazid Activity against Mycobacterium tuberculosis by Melatonin

Autor:	Dinie Hon, Eileen Hoal-van Helden, Paul D. van Helden, Ian Wiid, Carl Lombard
Rok vydání:	1999
Předmět:	endocrine system Tuberculosis chemotherapy Antitubercular Agents Microbial Sensitivity Tests Pharmacology Biology Antioxidants Mycobacterium tuberculosis Melatonin Pineal gland Isoniazid medicine Humans Pharmacology (medical) Biologic Response Modifiers fungi food and beverages Drug Synergism Long-term potentiation Biological activity biology.organism_classification Drug Resistance Multiple In vitro Infectious Diseases medicine.anatomical_structure Immunology hormones hormone substitutes and hormone antagonists medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy. 43:975-977
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.43.4.975
Popis:	The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b481586ee4ee10d9b655b4d74212d4 https://doi.org/10.1128/aac.43.4.975 Zobrazit plný text záznamu