The mitochondrial inner membrane AAA metalloprotease family in metazoans
| Autor: | Howard T. Jacobs, M. Katariina Juhola, Zahid H. Shah, Leslie A. Grivell |
|---|---|
| Přispěvatelé: | Molecular Biology and Microbial Food Safety (SILS, FNWI) |
| Rok vydání: | 2000 |
| Předmět: |
Saccharomyces cerevisiae
Biophysics Chaperone Biochemistry Metalloprotease AAA protein Structural Biology Genetics Animals Humans Gene family Mitochondrion Inner mitochondrial membrane Molecular Biology Phylogeny Caenorhabditis elegans Paraplegin biology Respiratory chain complex Metalloendopeptidases Intracellular Membranes Cell Biology biology.organism_classification Invertebrates Mitochondria Multigene Family Chaperone (protein) biology.protein Drosophila melanogaster |
| Zdroj: | FEBS Letters, 481, 91-95. Wiley-Blackwell |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(00)01989-x |
| Popis: | Three metalloproteases belonging to the AAA superfamily (Yme1p, Afg3p and Rca1p) are involved in protein turnover and respiratory chain complex assembly in the yeast inner mitochondrial membrane. Analysis of the completed genome sequences of Caenorhabditis elegans and Drosophila melanogaster indicates that this gene family typically comprises 3–4 members in metazoans. Phylogenetic analysis reveals three main branches represented, respectively, by Saccharomyces cerevisiae YME1, human SPG7 (paraplegin) and S. cerevisiae AFG3 and RCA1. mt-AAA metalloproteases are weak candidates for several previously studied Drosophila mutants. A full elucidation of the cellular and physiological roles of mt-AAA metalloproteases in metazoans will require the creation of targeted mutations. |
| Databáze: | OpenAIRE |
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